NanoSIMS 50/ 50L SIMS MICROPROBE FOR ULTRA FINE FEATURE ANALYSIS

 The CAMECA NanoSIMS 50 is an ion microprobe developed for trace element and isotopic analysis of ultra-fine features.
Among the unique features offered by the NanoSIMS 50 are:
       - the ability to extend SIMS analysis to extremely small areas or volumes (50 nm size in cesium, 150 nm in oxygen) while maintaining extremely high sensitivity at High Mass Resolution. This derives from the revolutionary coaxial optical design of the ion gun and secondary ion extraction, and from a new design of the magnetic sector mass analyzer. All other existing mag-SIMS or TOF-SIMS offer one or two of these parameters at the same time (sensitivity or lateral resolution or  high mass resolution).
        - the capability to measure up to five (NS50) or seven (NS50L) masses (ions) in parallel, ensuring perfect isotopic ratio from the same small volume, or perfect image superimposition.

 This outstanding performance opens new fields to which SIMS can be applied:
    - In geology and space science, the 50 nm SIMS lateral resolution together with the ability to measure isotopes precisely means that interplanetary dust particles and meteorite grains can be measured. The vast majority of these particles is much less than a micron in size. The analysis and classification of their isotopic signature helps model star formation. See for example "Samples of stars beyond the solar system: silicates grains in Interplanetary dust. Scott Messenger et Al.".
The NanoSIMS can now also work in multiple Faraday Cup configuration. In this mode, generally used with spot size of a few µm, one can improve the precision and external reproducibility of isotope ratio measurements down to the low sub-permil level. This new capability enlarges the application field in terrestrial geology.
    - In material research, the 50 nm SIMS lateral resolution together with the sensitivity improvements allow trace element (dopant) imaging and quantification at sub-micron scale, even in insulating materials (ex:Yttrium-Aluminum garnet). The application field is very large: dopant imaging, segregation, diffusion, particle and crack analysis in metallurgy, ceramics or semiconductors to cite a few.
    - In biology and pharmacology, the 50 nm SIMS lateral resolution allows intra-cellular analysis of inorganic traces in vegetal or animal tissues. The NanoSIMS isotopic ratio capabilities allow comparison in exactly the same subcellular compartments, of images of the distribution and measurement of the accumulation of several molecules labeled with different stable isotopes (e.g. 15N, 13C, 2H, 18O, 33S, 74Se, ...). See example: study on mouse cochlea. MIMS (Multiple Isotope Mass Spectrometry) opens a world of labeling possibilities impossible with autoradiography, and offers a much higher sensitivity.
    - In environmental microbiology, coupling stable isotope labeling experiment with optical FISH or in-situ EL-FISH or HISH allows for the first time to link the phylogenic identity of individual cells with their metabolic activity, in their natural environment. This has been applied to the study of marine bacteria, soil studies, bacterial mats.    

Check our "publications" or "application notes" pages to download scientific articles from our users and application leaflets.

The NanoSIMS 50 was designed by Pr. Slodzian and is manufactured by CAMECA under a UPS-ONERA license.